Unraveling the Mystery of Cyalis

You may want to ask "Cialis".

1. Drug-related information

1、pharmacological effects

- Tadalafil is a drug used to treat erectile dysfunction (ED) in men and is a phosphodiesterase type 5 (PDE5) inhibitor.

- Under normal circumstances, sexual stimulation causes the nerve endings and endothelial cells of the cavernous body to release nitric oxide (NO). NO activates guanylate cyclase and increases the level of cyclic guanosine phosphate (cGMP), which leads to smooth muscle relaxation and blood flows into the corpus cavernosum of the penis, causing erection. PDE5 hydrolyzes cGMP and reduces its concentration. Tadalafil inhibits the activity of PDE5 and increases the level of cGMP, which helps maintain the erectile function of the penis.

2、pharmacokinetics of

- Tadalafil is absorbed rapidly after oral administration, reaching peak plasma concentrations about 2 hours after oral administration under fasting conditions.

- The absolute bioavailability of tadalafil is not yet clear, and food has little effect on its absorption. Its plasma protein binding rate is high. It is mainly metabolized in the liver and is metabolized by CYP3A4 (cytochrome P450 3A4 enzyme). The metabolites are inactive. They are mainly excreted in the feces as metabolites, and a small part is excreted in the kidneys.

3、clinical application

- It is mainly used to treat male erectile dysfunction.

- To a certain extent, it can also be used to treat lower urinary tract symptoms caused by benign prostatic hyperplasia (BPH), because it relaxes the smooth muscle of the prostate and bladder neck and improves symptoms such as dysuria.

4、Dosage and Administration

- For the treatment of erectile dysfunction, the recommended starting dose is 10mg when taken on demand and before sexual intercourse. Depending on the individual's efficacy and tolerability, the dose can be increased to 20mg or reduced to 5mg.

- For a once-daily regimen, the recommended dose is 2.5mg, taken at approximately the same time every day, regardless of when to have sex.

- When treating benign prostatic hyperplasia, the common dose is 5mg once a day.

5、adverse reactions

- Common adverse reactions include headache, indigestion, back pain, myalgia, nasopharyngitis, etc.

- A small number of patients may experience more serious adverse reactions such as visual abnormalities and hypotension.

- Tadalafil should not be used simultaneously with nitrates such as nitroglycerin, as combination of the two may cause severe hypotension.