Tadalafil (Cialis): treating ED by muscle relaxation

tadalafil at 5 milligrams is a common dose of this drug.

1. Properties and mechanism of action

-Tadalafil is a selective phosphodiesterase inhibitor-5 (PDE-5). It works by inhibiting PDE-5 in penile tissues, allowing cyclic monophosphate guanosin to accumulate (cGMP). Increased cGMP causes relaxation of smooth muscles in the blood vessels of the penis, facilitating blood flow and obtaining and maintaining erection.

2. Medical uses

-it is mainly used in the treatment of erectile dysfunction (ED) in men. It has also been studied for other uses, such as pulmonary hypertension, as it can help relax pulmonary blood vessels by increasing cGMP.

-in the case of SD, it is usually recommended to take the pill approximately 30 minutes to 1 hour before early sexual activity. However, it can be effective for a longer period (up to 36 hours in some cases, giving tadalafil the commercial name of "the weekend pill").

3. Precautions and side effects

-precautions:

-it should not be taken in combination with nitrates, as interaction can cause a drastic drop in blood pressure. This is very dangerous and can lead to serious medical situations.

-they should be used with caution in patients with severe heart problems, uncontrolled hypertension, etc.

-side effects:

-the most common side effects include headache, facial blush, nasal congestion, back pain, myalgia, and abdominal pain. These effects are usually mild to moderate and disappear in most cases in a short period of time.