Tadalafil: A Drug for Treating Erectile Dysfunction.
Gui í a de Salud Masculina
tadalafil is a drug for the treatment of male erectile dysfunction (ED). Here are some of its features:
I. the mechanism of action
1 、Inhibition of PDE5 enzyme
In the cavernous tissue of male reproductive organs, there is an enzyme called phosphodiesterase 5 (PDE5). When sexual stimulation causes the release of nitric oxide (NO) from the corpus cavernosum nerve of the penis, NO activates guanylate cyclase, which increases the level of cyclic guanosine monophosphate (cGMP), relaxing the smooth muscle of the cavernous body and causing blood flow into the penis and erection.
Tadalafil reduces the degradation of cGMP by selectively inhibiting PDE5, thereby maintaining the level of cGMP in the sponge and helping the penis to erect and maintain its erection.
II. Characteristics of drugs
1 、Long-term effect
Tadalafil acts for a long time and is called "weekend pill". It can be effective for about 36 hours. Compared with other short-acting ED drugs (such as sildenafil, which takes about 4-5 hours), patients have more flexible sexual schedule after taking the drug and do not need to take emergency medication before sex.
2 、Validity
A large number of clinical trials have shown that tadalafil is effective in the treatment of erectile dysfunction caused by different causes (such as organic, psychological or mixed causes). It is significant in improving penile erectile hardness and increasing the success rate of sexual intercourse.
3 、Security.
Overall, tadalafil is safe at the recommended dose, with relatively mild side effects, such as headache, facial flushing, indigestion, nasal congestion, etc., which are usually short-lived and gradually diminished as the body adapts to the drug.
Tadalafil is not suitable for some people, such as those who are taking nitrates (such as nitroglycerin), as a combination of the two can lead to severe hypotension, which is a very dangerous condition.
Tadalafil is a prescription drug and needs to be used under the guidance of a doctor to ensure the safety and effectiveness of the drug.
1 、Basic information:
Tadalafil is a PDE5 inhibitor that is mainly used to treat male erectile dysfunction (ED), a common sexual dysfunction.
In addition to sildenafil (Sildenafil) and vardenafil (Vardenafil), tadalafil is also one of the widely used drugs to treat ED worldwide.
2 、Mechanism of action:
-PDE5 inhibitors increase the concentration of nitric oxide in the sponge by inhibiting phosphodiesterase 5 (PDE5), thus promoting vasodilation, enhancing blood flow, and helping to achieve and maintain erection.
3 、Clinical application.:
Tadalafil is approved by FDA and EMA for the treatment of ED and also for the treatment of pulmonary hypertension (PAH).
Tadalafil can significantly improve sexual function and quality of life in patients with ED.
As an effective PDE5 inhibitor, tadalafil plays an important role in the treatment of male erectile dysfunction. Because of its potential side effects and contraindications, patients should consult their doctor and follow the doctor's advice before use.
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