Tadalafil (tadalafil) 5mg is a drug dose specification for the treatment of erectile dysfunction (ED) and pulmonary hypertension (PAH).
Gui í a de Salud Masculina
I. Pharmacological action
1.In the treatment of erectile dysfunction
Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor. Under sexual stimulation, nerve endings and endothelial cells in the penile sponge release nitric oxide (NO). NO can activate guanylate cyclase and increase the level of cyclic guanosine monophosphate (cGMP), which in turn relaxes the smooth muscle and allows blood to flow into the penile cavernous body to cause an erection.
PDE5 can degrade cGMP. Tadalafil can improve the erectile function of penis by inhibiting the activity of PDE5 and increasing the concentration of cGMP.
two。In the treatment of pulmonary hypertension
-there is also the expression of PDE5 in pulmonary vascular smooth muscle cells. Tadalafil can increase the concentration of cGMP in pulmonary vascular smooth muscle cells after inhibition of PDE5, which leads to pulmonary vasodilation, reduce pulmonary artery pressure, and improve the symptoms and exercise ability of patients with pulmonary hypertension.
II. Usage
1.Treatment of erectile dysfunction
For most patients, when taking tadalafil on demand, the recommended initial dose is 10mg, which is taken before sex, and can be increased to 20mg or reduced to 5mg depending on individual differences in efficacy and tolerance.
-5mg dose can also be used as a daily low-dose long-term administration regimen, which can reach steady-state blood concentration after continuous administration for 3-5 days, thus providing a stable curative effect. It is more suitable for some patients who expect to maintain good erectile function at any time during natural sexual activity.
two。Treatment of pulmonary hypertension
For patients with pulmonary hypertension, the recommended dose is 40mg (once a day), but the specific dose adjustment needs to be determined by the doctor according to factors such as the patient's tolerance and the severity of the disease.
Matters needing attention
1.Adverse reaction
Common adverse reactions include headache, indigestion, back pain, muscle pain, nasal congestion, etc. These adverse reactions are generally mild to moderate and may be alleviated after medication for a period of time.
-in a few cases, serious adverse reactions may occur, such as sudden loss of vision or loss (non-arterial anterior ischemic optic neuropathy, NAION). Although this is extremely rare, if the patient has vision problems during the use of tadalafil, he should stop using it immediately and seek medical attention.
two。Contraindication
-patients who are taking any form of nitrate drugs (such as nitroglycerin, isosorbide dinitrate, etc.) are strictly prohibited from using tadalafil, as a combination of the two can lead to severe hypotension.
-it is prohibited for patients who are not allergic to Tadala.
Tadalafil must be used under the guidance of a doctor. Patients should consult a doctor in time if there is any discomfort or abnormality in the course of use. Before patients start using tadalafil, they should inform the doctor in detail about their medical history, other drugs being taken and whether they have a history of allergy, which will help doctors to accurately judge whether tadalafil is suitable for patients and work out a reasonable medication plan. During the use of tadalafil, patients should pay attention to observe their own physical reactions, especially in the initial medication stage, if the adverse reactions are obvious or persistent, they should also communicate with the doctor in a timely manner. so that the doctor can adjust the medication dose or change the treatment plan according to the actual situation.